慶應SFC 環境情報学部 AO入試(グローバル) 志望理由書 提出例(金井昭夫研究会向け)

  1. Professor Akio Kanai

Introduction of the discussion

Central dogma in molecular biology is the general principles concerning the transmission and expression of genetic information. Genetic information encoded in DNA is copied to messenger RNA (mRNA) (transcription), and protein biosynthesis is performed based on that information (translation).

In this important process, RNA functions as mRNA, ribosomal RNA (rRNA), and transfer RNA (tRNA).

 

As an unexpected by-product of the genome project, a large number of genes encoding non-coding RNA (ncRNA) were discovered. This ncRNA does not express its function after being translated into a protein, but is thought to have some function as an RNA molecule, and is now called functional RNA.

Later, accelerated transcriptome analysis revealed that ncRNA transcription occurred.

 

Finding the problem

NcRNAs transcribed from the genome range from as short as 20 bases to over 200 bases in length. Among them, 18-25 bases called microRNAs (microRNAs) are attracting attention as functional RNAs. Long ncRNAs.

 

miRNA belongs to the small RNA molecule family and is an RNA interference (RNAi) molecule that causes intracellular gene expression reduction (gene silencing).

Since miRNA is naturally present in cells, it is thought that it has a gene silencing mechanism in vivo.

 

Argument

Since RNA is involved in maintaining homeostasis in living organisms, its failure is expected to result in disease.

However, in any disease, the fundamental issue of whether the increased or decreased miRNA expression is the “cause” or “result” of each disease has not yet been elucidated.

If miRNAs involved in the onset of the disease are identified, there is no doubt that this will directly lead to therapeutic drug development. However, the mechanism of action has not yet been elucidated.

 

Conclusion

Therefore, I would like to elucidate the mechanism of miRNA gene silencing.

 

Examining the conclusion

By studying with Professor Akio Kanai, who is a prominent scholar as a pioneer in RNA research, and has achieved remarkable results in the field of RNA research so far, I am sure that I could obtain various perspectives regarding my research and it would open up new horizons for me.

Therefore, I believe that Keio University’s Faculty of Environment and Information Studies is the most suitable place for pursuing my research and social contributions, and I am aspiring to enter your school and study in your laboratory.

 

 

AO入試・小論文に関するご相談・10日間無料添削はこちらから

「AO入試、どうしたらいいか分からない……」「小論文、添削してくれる人がいない……」という方は、こちらからご相談ください。
(毎日学習会の代表林が相談対応させていただきます!)





Wechat(微信)はこちら!





▽ より詳しい講座内容はこちらから!

毎日学習会の慶應小論文対策
毎日学習会の慶應SFC小論対策
毎日学習会の慶應SFCAO対策
毎日学習会の慶應SFC情報対策
毎日学習会の慶應法FIT対策
毎日学習会の慶應文学部推薦対策
毎日学習会の慶應経済PEARL対策
毎日学習会の上智推薦対策
毎日学習会の早稲田推薦対策

コメントを残す

メールアドレスが公開されることはありません。 * が付いている欄は必須項目です